Dr. Alex Cross (Tyler Perry) is a psychologist and police lieutenant who lives in the Indian village neighborhood of Detroit with his wife, Maria (Carmen Ejogo), their children, Damon and Janelle, and his grandmother, Nana Mama. Upon learning that Maria is pregnant with their third child, Cross considers accepting a job as an FBI profiler, but fears Maria's reaction, as it would require them to relocate to Washington, D.C. Meanwhile, a man called Picasso (Matthew Fox) participates in an underground mixed martial arts match, where he flirts with businesswoman Fan Yau (Stephanie Jacobsen). After brutally beating his opponent, Picasso is invited to Fan Yau's house in Grosse Pointe. There, he sedates, tortures, and kills her.
Police captain Richard Brookwell (John C. McGinley) calls Cross and his partner, Tommy Kane (Edward Burns), to the crime scene. On the way there, Cross tells Kane about Maria's pregnancy and the FBI's offer, and Kane reveals that he is secretly dating their colleague, Monica Ashe (Rachel Nichols). Investigating Yau's murder, Cross deduces that Picasso is a professional assassin, and finds a sketch left behind by Picasso revealing that his next target is a businessman, Erich Nunemarcher (Werner Daehn). Cross, Kane and Ashe go to Nunemarcher's office, but he dismisses their claims. Picasso manages to enter the building, but is prevented from killing Nunemarcher by Cross
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